Seal structuring and membrane integration

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Some applications in life-sciences require microfluidic devices or flowcells to be coated with sensitive bio-molecules, such as DNA primers. One possibility to coat the surface is to perform the coating before the flow cell is closed. That leads to  specific requirements to the sealing process. Thus, harsh chemicals or high temperatures must be avoided as those would ruin the bio-molecules.

Micronit has developed a flexible technology to create gaskets on glass that form the outer shape of the flowcell. The flowcell is created with a glass covering the gasket and applying a slight pressure, e.g. inside a chip holder, that seals the chamber. With this technology glass or fused silica devices can be sealed at room temperature. Even resealable devices can be created.The material used for the gasket is chemically inert and can be used with most solvents. The unique technology allows Micronit to customize flowcells at a relatively low cost with short turnaround times.

With a high degree of freedom this technology is suitable to create almost any design and a wide range of heights. Furthermore it can easily be integrated with other techniques such as glass-etching or the application of thin metal layers.

Application Examples:

  • Low cost flowcells for cell culturing
  • Flowcells for DNA, RNA or protein arrays
  • Resealable flowcells for SPR applications
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