Integrated Microfluidic Environment for solid-state nanopore sensors

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Integrated Microfluidic Environment for solid-state nanopore sensors

Procedia Engineering, Volume 47, 2012, Pages 13–16

Z. Feketea, Corresponding author contact information, E-mail the corresponding author, G. Huszkaa, A. Pongrácza, Gy. Jágerszkib, R.E. Gyurcsányib, E. Vrouwec, P. Fürjesa

a MEMS Lab, Inst. for Technical Physics & Materials Science, Research Centre for Natural Sciences – HAS, P.O.Box 49, H-1525 Budapest, Hungary

b Budapest University of Technology and Economics, H-1111 Budapest, Hungary

c Micronit Microfluidics BV, Colosseum 15, NL-7521 PV Enschede, The Netherlands

Z. Feketea, Corresponding author contact information, E-mail the corresponding author, G. Huszkaa, A. Pongrácza, Gy. Jágerszkib, R.E. Gyurcsányib, E. Vrouwec, P. Fürjesa

a MEMS Lab, Inst. for Technical Physics & Materials Science, Research Centre for Natural Sciences – HAS, P.O.Box 49, H-1525 Budapest, Hungary

b Budapest University of Technology and Economics, H-1111 Budapest, Hungary

c Micronit Microfluidics BV, Colosseum 15, NL-7521 PV Enschede, The Netherlands

Abstract

The micro- and nanotechnology based biosensing principles open up new possibilities towards the development and realisation of robust, user-friendly and cost-effective in-vitro diagnostic platforms. Furthermore, label-free and multi- analyte detection is envisioned to allow more accuracy and higher throughput in clinical diagnostic. The bioanalytical systems are expected to integrate the nanoscale transducers with interface chemistry, and bio-receptors as well as the microfluidics, control software and hardware. The final goal of this work is to develop nanopore based multi- parametric biosensing platform, applicable for label-free detection of blood marker proteins of cardiovascular symptoms. More->

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