Electrochemical Impedance Spectroscopy Chip
The use of electrochemical impedance spectroscopy (EIS) as an inline monitoring system for the accurate detection and counting of droplets, cells or particles has now been realized in a single compact microfluidic chip. The EIS chip (figure 1) is designed to give accurate detection as particles or cells pass between the out-of-plane electrodes. These specially designed out-of-plane electrodes (figure 2B) achieve a more parallel and uniform electric field when compared to in-plane electrodes (figure 2A). This increased field uniformity enables better particle detection by data acquistion systems, such as those designed by our development partner Zurich Instruments. Additional stability to the inline monitoring is enabled by Fluigent’s accurate flow control systems. Micronit has also developed an interfacing system (figure 3) based on the Fluidic Connect Pro platform, featuring both fluidic and electrical interfacing to the chip.