A microtiter plate is a flat plate with multiple wells used as small test tubes. Titer plates are commonly used as research tools for the preservation and handling of chemical and biological samples.
Titer plates can be used for various research applications, like:
- high throughput screening (HTS)
- Polymerase Chain Reactions (PCR)
- Enzyme-Linked Immunosorbent Assay (ELISA)
The titer plates can be manufactured from various glass types, like borosilicate glass or fused silica (quartz). For confocal microscopes thin glass layers can be used (down to 100 µm).
Technique
Microtiter plates are manufactured by bonding two glass layers on each other. With a powderblasting process the holes in the top plate are created. By using this technique, the shape of the wells is flexible; they can be round or rectangular. The sidewalls of the wells are not completely vertical, but sloped at an angle of approximately 70 degrees. For evaporation purposes this angle can also be 110 degrees.
One of the major advantages of the micropowderblasting process is the use of a lithographic mask. This makes the shape of the holes or wells completely flexible and it assures a very good position accuracy.
With a direct bonding technique of the two glass layers, no other materials (such as glue) are involved.
Reference: Chemical Sensor ArraysMicronit has developed 140 wells glass microtiter plates for a university research project. The titer plates enable to apply high throughput screening techniques for the development of new sensors.
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Standard microtiter plate Micronit offers a standard microtiter plate with 96 wells and a bottom thickness of 145 µm. This titer plate is available off-the-shelf in the Micronit webshop.